Connecting biopharmas with the right preclinical cancer models and CRO partners

Cancer Models Forum

Posted by Henrietta, December 2020

Case Study: how our new platform features make it possible to do your own CMS

We recently launched two brand-new features on our Cancer Models Platform:

  • A multiple gene filter, allowing users to perform searches for models containing specific gene combinations or for multiple models containing different genes.

  • A gene variant filter, enabling users to perform more specific model searches by selecting specific genes and either viewing all available gene variants or specific variants for each gene.

In our previous blog post, we covered the story behind our newest platform features, as well as what benefit they can provide to biopharma researchers working in oncology and what makes them unique to other search platforms. In this blog post, we’re going to be showing you a real-world example of how our new platform features can be used to perform more effective model searches across our Cancer Models Platform. To do this, we will be comparing the results of our new platform search capabilities to results from a recent Cancer Models Scout search we performed for a client.

What is the difference between the Cancer Models Platform and the Cancer Models Scout?

CMP vs CMS


Results of the Cancer Model Scout search

The example Cancer Model Scout report we will be using had the following search criteria:

  • Model type: PDX
  • Cancer types/subtypes: NSCLC
  • Molecular characteristics: KRAS mutations, STK11 mutations, both KRAS and STK11 mutations together

Based on this brief, we performed a search across 265 NSCLC models in our inventory from 3 different CROs, and the search included models with any SNV that affects the protein coding sequence. From outside our inventory, we also identified 292 models across six CROs that could be further characterised to determine the KRAS and STK11 profile. Our results returned 34 full matches, with 26 models for KRAS mutations only, 2 models for STK11 mutations only and 6 models for KRAS and STK11 mutations combined.

How a direct search using our new Cancer Model Platform features compares

Performing the same search for KRAS and STK11 mutations across the 8000+ models on our Cancer Models Platform returned 27 total results, with 18 models for KRAS mutations only, 6 models for STK11 mutations only and 3 models for KRAS and STK11 mutations combined. Molecular data was available on request for all models, with growth curves also available for 19 models and drug response data available for 7 models.

CMP search for CMS89

By clicking on a search result, further details about the genetic profile of each cancer model can be displayed, including the gene(s) mutated, protein position of the mutation(s), amino acid change(s) and the consequence of each gene mutation. This enables a high degree of specificity when comparing and selecting cancer models.

CMS89 genes and variants


Benefits of using our new Cancer Models Platform features

With precision medicine approaches to therapy becoming increasingly prevalent in cancer drug development, selecting the right preclinical cancer model for early-stage research will have a major impact on the translatability of results to patients. Therefore, it is imperative that oncology researchers can easily find, access and compare data on the different preclinical models to have greater confidence in selecting the best possible models for their studies.

Our new Cancer Model Platform features provide a quick and easy way to search across the thousands of models in our inventory to find those that best match the genomic, treatment and other model specifications required for your next preclinical study. Whilst a Cancer Model Scout search may take us a few weeks to complete, the platform can be searched by users instantaneously and within minutes provide information on a significant number of relevant models. In addition, whilst a Cancer Model Scout search will only provide results based on the specific client brief, having access to our platform enables you to perform an unlimited number of searches for any cancer, gene or treatment combinations, which is useful should you change your mind about the types of models you're looking for.

Ready to try out our new search features? Visit the  Cancer Models Platform  now or connect with us at info@repositive.io to learn more about how to get access!