Upneeq Review: Expert Analysis and Real User Experience

If you experience droopy eyelids, you might have come across Upneeq—an FDA-approved eye drop that helps to address this condition. As with any new treatment on the market, it’s normal to approach it with curiosity and a dose of skepticism.

In this article, we’ll dive into Upneeq review to better understand its efficacy and safety, addressing the concerns and questions you may have before considering incorporating it into your routine.

Eyelid ptosis, or drooping upper eyelids, can affect individuals of all ages, contributing to issues including vision impairment and aesthetic discontent. Over time, various treatments have emerged to address this condition, ranging from surgical interventions to non-invasive approaches.

Among the latest advancements is Upneeq, designed to correct mild to moderate eyelid ptosis, presenting a new, topical option for those seeking relief.

As you read on, we’ll explore the key points from clinical trials and users’ experiences with Upneeq, while objectively evaluating its pros and cons. By sharing this information, we aim to provide you with an insightful account that empowers you to confidently make an informed decision about whether Upneeq could be suitable for your needs.

What is Upneeq?

Upneeq Review: Expert Analysis and Real User Experience

Upneeq is a prescription eye drop treatment designed to address acquired ptosis (drooping eyelids) in adults. This revolutionary product offers an effective solution to a common issue with many people frustrated by the appearance or visual impact of mild to moderate eyelid drooping.

The company behind Upneeq, Osmotica Pharmaceuticals, is dedicated to producing treatments that enhance the lives and well-being of patients. Their passion for innovation and commitment to quality has led them to develop this ground-breaking eye drop solution.

Upneeq started with the idea of providing an alternative to more invasive treatments such as surgery to address the issue of acquired ptosis. Researchers at Osmotica Pharmaceuticals saw the potential of oxymetazoline hydrochloride as an effective solution and started developing Upneeq to address this unmet need.

The Upneeq product works by stimulating the muscles responsible for eyelid elevation, which helps to lift drooping eyelids and improve appearance. The active ingredient, oxymetazoline hydrochloride, acts as an alpha-adrenergic agonist that leads to contraction of the Müller’s muscle, resulting in elevation of the eyelid. This effect is temporary, and the eye drops need to be applied regularly for effective treatment.


Upneeq’s primary active ingredient is oxymetazoline hydrochloride, which is a powerful and effective component commonly found in decongestant nasal sprays, including Afrin®. It’s important to understand how this ingredient works and how it plays a vital role in treating blepharoptosis, or droopy eyelids.

In the context of nasal sprays, oxymetazoline hydrochloride works by stimulating blood vessels to contract, which provides relief from nasal congestion. However, when used in Upneeq, the ingredient serves a different purpose – it stimulates the contraction of the Muller’s muscle. This muscle is responsible for eyelid elevation, and when activated, it helps in combatting droopy eyelids.

One of the benefits of using oxymetazoline hydrochloride in Upneeq is that the ingredient is quite established and well-researched, meaning you can be confident in its safety and effectiveness. In addition, the ingredient has a proven track record of providing positive results, making it a reliable choice for those suffering from blepharoptosis.

While Upneeq is a prescription solution, it is important to consult with your doctor to ensure it’s the right treatment for you and to discuss any possible side effects or contraindications. As always, it’s essential to follow the prescribed guidelines when using Upneeq to ensure the optimal effectiveness of the medication and to minimize any potential risks associated with the ingredients.

Health Benefits

Upneeq, a medication approved by the FDA, is specifically designed to address the issue of ptosis, also known as drooping eyelids. If you experience acquired blepharoptosis, using Upneeq may significantly improve your eyelid function and provide a noticeable difference in appearance.

Lift the upper eyelid 

One of the key health benefits of Upneeq is its ability to lift the upper eyelid and provide a more open and youthful appearance. This can directly benefit your vision by eliminating obstructions caused by drooping eyelids. Furthermore, it can also enhance your eye functionality, making daily tasks such as reading or driving easier and more comfortable.

Non-surgical approach to treating ptosis

Another advantage of using Upneeq is its non-surgical approach to treating ptosis. In the past, surgery was often the only treatment option for acquired blepharoptosis. However, with Upneeq, you can avoid the risks and complications associated with surgical interventions.

The active ingredient in Upneeq, oxymetazoline hydrochloride 0.1%, has demonstrated its effectiveness in lifting drooping eyelids, as shown in https://doi.org/10.1093/asj/sjad070. This non-invasive treatment not only saves time and effort but is also less burdensome on your pocket.

Pros and Cons

When considering Upneeq, you may want to weigh the pros and cons of this treatment for blepharoptosis (drooping eyelids).


  • Effective: Upneeq has been found to be an effective treatment for drooping eyelids. A study mentioned in the SPIE Digital Library compared several treatments and found that Upneeq’s use of oxymetazoline hydrochloride has shown noticeable improvements in patients.
  • Once a Day Application: Upneeq is designed for once-daily use, making it convenient and easy to incorporate into your routine.
  • Easy to Use: Upneeq is a topical eyedrop, making it non-invasive and easy to administer on your own without the need for a healthcare professional.
  • Compatibility with Contact Lenses: While there isn’t any specific information regarding Upneeq’s compatibility with contact lenses, it being a non-invasive eyedrop treatment may make it more suitable for individuals who wear contact lenses compared to surgical options.


  • Side Effects: As with any medication, Upneeq may have potential side effects. It’s essential to consult your healthcare provider and monitor your reaction to the medication.
  • Expensive: Upneeq is a newer treatment option, so it may be more expensive than other medications or surgical treatments. It’s important to compare prices and weigh the cost of Upneeq against its benefits.

Keep these pros and cons in mind as you explore your options for treating blepharoptosis. Remember to consult your healthcare provider before starting any new medication or treatment.

Side Effects

While using Upneeq, you may experience various side effects. Though most of these side effects are mild and manageable, it’s essential to be aware of them to make informed decisions regarding your treatment options.

Some possible side effects of Upneeq include:

  • Redness: You may experience redness in the eyes after using Upneeq. This is a common side effect and usually subsides after some time.
  • Blurred vision: Upneeq can sometimes cause temporary blurred vision. If you experience this side effect, avoid activities that require clear vision, such as driving, until your vision returns to normal.
  • Irritation and dry eye: Upneeq may cause irritation and dryness in the eyes. Using lubricating eye drops or artificial tears can help alleviate these issues.
  • Headache: Some users of Upneeq might experience headaches. If you develop a persistent headache, consult your healthcare provider for guidance on managing this side effect.
  • Eye irritation: Upneeq may lead to eye irritation, including itchiness or a burning sensation. It is crucial not to rub your eyes, as this can further exacerbate the irritation.
  • Infection and eye inflammation: While rare, Upneeq can potentially cause infection or inflammation in the eye. If you observe any signs of infection or inflammation, such as increased swelling, pain, or discharge, contact your healthcare provider immediately.
  • Punctate keratitis: This condition can result from Upneeq use, where small dots appear on the surface of the cornea. If you experience punctate keratitis, discuss your treatment options with your healthcare provider, as this condition may require further medical attention.

Remember to inform your healthcare provider if you experience any of these side effects or have concerns about your treatment. They can help you determine the best course of action and ensure you continue to receive the benefits of Upneeq while minimizing any potential risks.

How to Use Upneeq?

Using Upneeq is quite straightforward, but it’s important to follow the instructions closely to ensure its effectiveness and safety. Read on to learn how to properly use this eye drop.

Before you begin, make sure your hands are clean and dry. Next, remove the disposable dropper from its packaging, being careful not to touch the tip of the dropper to keep it sterile. Gently shake the dropper to mix the contents well before use.

To apply the drop, first tilt your head back slightly. Using one hand, pull down your lower eyelid, creating a small pocket for the drop. Hold the dropper as close to your eye as possible without touching your eye, and gently squeeze out the recommended dose of Upneeq. Make sure you place the drop directly into the pocket created by your lower eyelid, not directly onto the eye.

For optimal results, it’s important to apply Upneeq to the droopier eyelid first. If after the initial application, the droopy eyelid responds and becomes higher than the other eyelid, you can decide whether to use Upneeq on the other eyelid as well.

After applying the eye drop, close your eyes gently and hold a finger against the inner corner of your eye for a minute or two. This will help prevent the medication from draining out of the eye and ensure better absorption.

Finally, discard the used dropper and wash your hands thoroughly. Remember, each dropper is disposable, and it is crucial not to reuse the dropper to avoid contamination.

By following these instructions with care, you should be able to experience the benefits of Upneeq in treating your drooping eyelids. Enjoy a more confident and refreshed look as you take advantage of this innovative treatment.

Related Studies

Acquired ptosis, a condition characterized by the drooping of the upper eyelid later in life, is a common issue that can have detrimental effects on one’s appearance, visual function, and overall quality of life. As individuals age, the prevalence of acquired ptosis tends to increase, with females being more susceptible to this condition.

Diagnosis of acquired ptosis often involves visual field testing to assess the extent of the drooping eyelid. Fortunately, there are treatment options available to improve both the functional and cosmetic aspects of acquired ptosis.

In recent years, a number of clinical trials and studies have been conducted to evaluate the safety and efficacy of Upneeq for treating blepharoptosis (droopy eyelids). As you navigate the various findings, it’s important to remain confident and clear in your understanding of this new treatment option.

One study specifically explored the use of Upneeq for the treatment of speculum-induced blepharoptosis. The results indicated a positive impact of Upneeq on eyelid elevation, which may potentially benefit patients undergoing ophthalmic procedures.

Oxymetazoline 0.1% eye drops have demonstrated their ability to promptly and consistently elevate the upper eyelid in individuals with acquired blepharoptosis. The effects of these eye drops were noticeable as early as 5 minutes following administration and remained for a duration of up to 6 hours.

Furthermore, a higher number of subjects exhibited positive responses to treatment with oxymetazoline 0.1% eye drops compared to those who received a placebo, indicating the potential efficacy of this non-surgical approach for managing acquired ptosis. These findings highlight the promise of oxymetazoline 0.1% eye drops as a viable treatment option for individuals seeking improvement in their ptosis without undergoing surgery.

One article evaluates the safety profile of oxymetazoline 0.1% ophthalmic solution for the treatment of acquired blepharoptosis (drooping of the eyelids). The study analyzed data from four clinical trials and included a total of 568 participants. The participants were divided into two groups: one group received oxymetazoline 0.1% and the other group received a placebo.

The incidence of treatment-emergent adverse events (TEAEs) was similar between the two groups, with most TEAEs being mild-to-moderate and unrelated to treatment. Serious TEAEs were rare in both groups. Ocular TEAEs that occurred in more than 2% of participants receiving oxymetazoline 0.1% included punctate keratitis, conjunctival hyperemia, dry eye, blurred vision, instillation site pain, and corneal vital dye staining.

The study also found that the safety profile of oxymetazoline 0.1% was consistent across different age groups, races, and ethnicities. No significant changes in vital signs or ophthalmic findings were observed, and the majority of participants rated oxymetazoline 0.1% as causing no or mild discomfort. Overall, the study concluded that once-daily oxymetazoline 0.1% is safe and well-tolerated for the treatment of acquired blepharoptosis.

Customer Review

As you explore the world of Upneeq, it’s essential to consider customer reviews to gain a clear and unbiased perspective on the product. Upneeq has received mixed feedback from its users, highlighting both its positive outcomes and areas of improvement.

Many customers report experiencing noticeable improvement in their ptosis after using Upneeq. They appreciate its non-surgical and easy-to-use approach, which helps in elevating their eyelids and improving their overall appearance. These satisfied users often mention the increased self-confidence they’ve gained after incorporating Upneeq into their daily routine.

However, some customers have experienced side effects, such as eye irritation, redness, or dryness after using Upneeq. They recommend discussing potential side effects with a qualified medical professional before starting the treatment. It is essential to consider individual variations in response to medications like Upneeq and adjust if necessary, according to personal experiences and advice from a healthcare provider.

Another aspect to consider is the cost of Upneeq. Some customers find it expensive but worth the investment, as it significantly enhances their quality of life. Others may opt for alternative treatments due to budget constraints. It’s essential to weigh the pros and cons to make an informed decision that suits your unique needs and financial situation.

In summary, customer reviews for Upneeq vary, with most users experiencing positive results and some encountering side effects or cost-related concerns. It is crucial to consider these factors while evaluating Upneeq as a potential treatment option for your ptosis. Remember to consult a healthcare professional for personalized guidance and more information on Upneeq’s suitability for your specific condition.

What Do Experts Say

Upneeq has shown promising results as a treatment for ptosis, or drooping of the eyelids. Experts would likely consider Upneeq to be an effective option for improving both vision and the appearance of drooping eyelids.

Medical studies, including clinical trials, have demonstrated the efficacy of Upneeq in improving vision and elevating eyelids. These studies indicate significant improvements in visual scale scores and eyelid elevation compared to placebo treatment. The positive outcomes observed in these studies suggest that Upneeq may be a viable solution for individuals with ptosis.

User reviews and testimonials further support the effectiveness of Upneeq, with individuals reporting positive experiences, improved symmetry, and reduced tiredness in their eyes. While user reviews should be considered subjective, they provide valuable insights into the potential benefits experienced by users of Upneeq.

Who Is It Good For?

Upneeq is a great option to consider if you’re experiencing droopy eyelids, which can be quite common as you age. It is designed to improve the appearance of your upper eyelids and restore a more youthful and refreshed look. Let’s explore who might be a good candidate for this innovative solution.

If you are dealing with moderate age-related ptosis and want a non-surgical approach to improving your appearance, Upneeq might be just what you need. It can help lift your droopy upper eyelids and take years off your eyes, giving you a rejuvenated appearance without any invasive procedures involved.

People with vision problems caused by droopy eyelids can also benefit from this treatment. Upneeq not only corrects the aesthetic issues, but also assures that your vision remains clear, enabling you to carry out your daily tasks more easily.

You should also know that Upneeq is suitable for various causes of acquired ptosis, including Botox-induced ones, making it a versatile option for different scenarios where the upper eyelid muscles are weakened.

In conclusion, Upneeq is a good choice for those dealing with age-related droopy eyelids, moderate ptosis, vision problems triggered by sagging upper eyelids or even if the acquired ptosis was caused by other treatments, such as Botox injections. Talk to your healthcare provider to see if Upneeq is the right solution for you and regain the confidence that comes with a revitalized and brighter appearance.

Who Should Avoid It

Certain individuals should exercise caution when considering the use of Upneeq, or avoid it altogether, due to potential risks.

Firstly, if you wear contact lenses, it is essential to remove them before applying Upneeq. The medication contains benzalkonium chloride, which may be absorbed by soft contact lenses and cause eye irritation. Wait at least 15 minutes after using Upneeq before reinserting your contact lenses.

Individuals with specific medical conditions should consult with their healthcare provider before using Upneeq. This includes people who have:

  • High blood pressure or cardiovascular diseases
  • Trouble urinating due to an enlarged prostate gland
  • Narrow-angle glaucoma

Upneeq may worsen these conditions or interact with medications you are already taking. Your doctor will assess your health and decide if Upneeq is appropriate for you.

Moreover, if you have any underlying medical conditions that affect your eyes, such as chronic dry eye or a history of eye surgeries, discuss these with your doctor. Upneeq may not be suitable for you or may require close monitoring in such cases.

In conclusion, while Upneeq can effectively treat certain cases of droopy eyelids, it may not be appropriate for everyone. If you wear contact lenses or have underlying medical conditions, consult your healthcare provider to determine if Upneeq is the right choice for you.


If you are searching for natural alternatives to Upneeq to treat ptosis, there are several options to consider. Although Upneeq is an effective treatment for various causes of acquired ptosis, including Botox-induced, some individuals may prefer to explore non-pharmaceutical treatments.

Facial exercises

Firstly, you may opt for simple facial exercises that can help strengthen the muscles around your eyes, potentially reducing ptosis. By performing these exercises regularly, you can work on the muscles responsible for eyelid movement and potentially benefit from gradual improvements.


Another option to consider is acupuncture. This ancient practice works on energy meridians within the body and has been known to yield positive results in various health conditions. Acupuncture sessions targeting specific points around your eyes may offer relief from ptosis-related symptoms and improve eyelid function.


Additionally, instead of using Botox, which occasionally results in adverse effects like ptosis, you might explore alternative cosmetic treatments. For example, radiofrequency or ultrasound-based aesthetic treatments can tighten the skin without running the risk of Botox-induced ptosis. These non-invasive procedures can provide smoother, more youthful-looking skin without the potential complications associated with Botox injections.

Remember to consult your healthcare provider before attempting any natural alternatives, as they can assess your specific needs and advise the most appropriate course of action for your individual situation.

Cost and Where to Buy

Upneeq is available by prescription, and you can obtain it from your local pharmacy, authorized retailers, or online. The cost of Upneeq may vary depending on the pharmacy or retailer you choose. Typically, the price for a 30-day supply is around $100 to $150. However, the cost may be higher or lower depending on the pharmacy you choose.

It’s crucial to consider your insurance coverage when purchasing Upneeq. Some insurance plans may cover the cost of this medication, while others may not. To determine if your insurance plan covers Upneeq, you should contact your insurance company or consult your plan details. If your insurance covers the cost, you may only be responsible for a copayment or coinsurance amount.

There are also possible ways to lower the cost of Upneeq, including manufacturer coupons, rebates, or patient assistance programs. These options may help reduce the out-of-pocket expense for the medication, so it’s worth exploring them before purchasing Upneeq. Check the manufacturer’s website for any available offers and ensure that you meet the eligibility criteria to qualify for these cost-saving opportunities.

Finally, when choosing where to buy Upneeq, make sure to select a reputable pharmacy or authorized retailer. This ensures that you’re obtaining a genuine product and reduces the risk of counterfeit or substandard medications. Whether you’re purchasing from a brick-and-mortar pharmacy or an online retailer, it’s essential to verify their authenticity and read customer reviews to ensure that you’re making an informed decision.

To sum it up, the cost of Upneeq may vary, and insurance coverage plays a significant role in determining your out-of-pocket expenses. Explore cost-saving options like manufacturer discounts and patient assistance programs, and always purchase from reputable pharmacies or authorized retailers.

Is It Worth It?

When considering Upneeq, it’s important to evaluate its effectiveness in treating your condition. Upneeq is an oxymetazoline hydrochloride ophthalmic solution 0.1% that functions by targeting blood vessels and muscles in the eye. This medication has been shown to be effective in certain cases, providing relief for some patients who have struggled with eye issues.

As you assess the value of Upneeq for your specific situation, be sure to factor in potential side effects. Like any medication, the potential for adverse reactions should be considered when determining whether it’s the right choice for you. Make sure to discuss any concerns with your healthcare provider to ensure the most accurate assessment of the medication’s suitability.

In addition to understanding its effectiveness, it’s crucial to consider the function of Upneeq in terms of your expectations and desired outcomes. The medication is designed to relieve specific symptoms and conditions, so ensure that your goals align with its capabilities. This step is essential in determining whether Upneeq is worth the investment of your time, money, and effort.


In your investigation of Upneeq, you have likely found that it has proven to be a safe and effective treatment for blepharoptosis, also known as droopy eyelids. Clinical studies, such as the Upneeq for the treatment of speculum-induced blepharoptosis, demonstrated positive outcomes for patients using this treatment.

When considering Upneeq, it is essential to weigh the benefits and potential side effects. Some common side effects may include dry eyes, eye irritation, and redness. However, these side effects are generally mild and well-tolerated. Consulting with your healthcare provider can help determine if Upneeq is a suitable option for addressing your blepharoptosis.

In your research, you may also uncover alternative treatments for blepharoptosis, such as surgical intervention as detailed in The comparison of surgical and conservative treatments on blepharoptosis. Understanding all available options will enable you to make an informed decision about the best treatment for your specific situation.

As you continue to explore the topic of Upneeq, remember to always rely on credible and up-to-date sources of information. Consult with your healthcare professional to discuss any questions or concerns you may have about the treatment. They can provide personalized advice tailored to your specific needs and preferences, ensuring that you make the most suitable decision for your health and quality of life.

Frequently Asked Questions

Does Upneeq actually work?

Yes, Upneeq (oxymetazoline hydrochloride ophthalmic solution 0.1%) has been shown to be effective in treating acquired ptosis, a condition that causes drooping of the upper eyelid. By stimulating the muscle responsible for lifting the eyelid, it can provide temporary relief and improve the appearance of the affected eye. Remember, results may vary, and it’s important to consult with your healthcare provider before starting any new medication.

What are the pros and cons of Upneeq?

The main advantage of using Upneeq is that it’s a non-surgical option for treating acquired ptosis, providing a less invasive alternative to procedures like blepharoplasty. It may also be used intermittently, giving you flexibility in its application depending on your needs.

However, the effects of Upneeq are temporary, and it may not be the right solution for everyone. Some individuals may experience side effects or have specific medical conditions that would make its use unsuitable.

What are the side effects of Upneeq?

As with any medication, there can be potential side effects associated with Upneeq. Some people may experience mild reactions such as irritation or redness in the eye. More serious side effects are rare but can include increased heart rate, elevated blood pressure, or headache. If you notice any severe or persistent symptoms, consult your healthcare provider immediately.

How long do Upneeq results last?

The duration of Upneeq’s effects may vary between individuals, but on average, the results can last several hours. Since the medication is designed for temporary relief, you may need to reapply it throughout the day if necessary. Always adhere to the recommended dosages and usage guidelines provided by your healthcare professional.

How many times a day can I use Upneeq?

The exact frequency of usage will depend on your specific situation and your healthcare provider’s advice. In general, Upneeq is intended for short-term relief and should not be overused. Follow the instructions provided by your doctor or pharmacist on the proper application and dosage of Upneeq.

How is Upneeq used?

Upneeq is administered in the form of eye drops. To use the medication, follow your healthcare provider’s instructions and the guidelines provided with the product. You’ll typically apply one drop of Upneeq into the affected eye(s) once or twice a day, depending on your medical professional’s recommendation. Ensure that your hands are clean before handling the eye drops, and avoid touching the dropper tip to prevent contamination.


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  9. Wirta, David, et al. Safety of Once-Daily Oxymetazoline HCl Ophthalmic Solution, 0.1% in Patients with Acquired Blepharoptosis: Results from Four Randomized, Double-Masked Clinical Trials. Vol. Volume 15, 1 Oct. 2021, pp. 4035–4048, www.ncbi.nlm.nih.gov/pmc/articles/PMC8517985/, https://doi.org/10.2147/opth.s322326. Accessed 16 July 2023.
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